| Primary Identifier | IPR018862 | Type | Family |
| Short Name | eIF4E-T |
| description | This entry represents a group of eIF4E binding proteins, including eIF4E transporter (eIF4E-T) from mammals, cup protein from D. melanogaster and ifet-1 from C. elegans. Protein cup functions in Smaug-mediated translational repression [, ]. Ifet-1 is a broad-scale translational repressor in C. elegans [, ]. eIF4E-T is the transporter protein for shuttling the mRNA cap-binding protein eIF4E protein, targeting it for nuclear import. eIF4E-T contains several key binding domains including two functional leucine-rich NESs (nuclear export signals) between residues 438-447 and 613-638 in the human protein. The other two binding domains are an eIF4E-T-binding site, between residues 27-42 in , and a bipartite NLS (nuclear localisation signals) between 194-211, and these lie in family eIF4E-T_N. eIF4E-T is the eukaryotic translation initiation factor 4E that is the rate-limiting factor for cap-dependent translation initiation []. |
