| Primary Identifier | IPR041204 | Type | Domain |
| Short Name | RIG-I-like_C |
| description | This entry represents the C-terminal domain of RIG-I and RIG-I-like receptors, which are key cytosolic pattern-recognition receptors of the vertebrate innate immune system that forms the first line of defence against RNA viral infection [, , ]. ATP-dependent RNA helicase DHX58 (also known as RIG-I-like receptor LGP2) acts as a regulator of RIG-I and IFIH1/MDA5 mediated antiviral signaling as it cannot initiate antiviral signalling due to the lack of the CARD domain required for activating MAVS/IPS1-dependent signalling events. RNA binding to RIG-I is mediated both by the C-terminal domain and by the helicase domain. The C-terminal domain specifically binds the 5'-triphosphate end with a 10-fold higher affinity compared to 5'OH-dsRNA []. |
