| Primary Identifier | IPR004518 | Type | Domain |
| Short Name | MazG_cat |
| description | This domain is found in a group of prokaryotic proteins which includes Escherichia coli MazG, which hydrolyses all canonical nucleoside triphosphates but it also might have a 'housecleaning' function by hydrolysing noncanonical NTPs, whose incorporation into the nascent DNA leads to the increased mutagenesis and DNA damage [, , ]. Phylogenetic distribution studies of this domain revealed that it commonly appears as two domains in tandem, although there are single-domain analogs. In E. coli there are two tandem globular domains, in which the NTPase activity was observed only at the C-terminal domain []. |
