| Primary Identifier | IPR028532 | Type | Family |
| Short Name | FNBP1/FBP17 |
| description | Formin-binding protein 1 (FNBP1, also known as formin-binding protein 17) contains a N-terminal FER-CIP4 homology (FCH) domain and a C-terminal SH3 domain. It belongs to the CIP4 (Cdc42 interacting protein-4) subfamily of the F-BAR protein family. F-BAR proteins (F for FCH, Fer-CIP4 homology domain) are proteins with an extended CIP4-Fer domain. The F-BAR proteins have been implicated in cell membrane processes such as membrane invagination, tubulation and endocytosis []. FNBP1 was originally isolated as a molecule that binds to the proline-rich region of formin []. It induces tubular membrane invaginations and participates in endocytosis []. It interacts with sorting nexin, SNX2, and is linked to acute myelogeneous leukemia []. |
