| Primary Identifier | IPR028573 | Type | Family |
| Short Name | Maf/V-MAF |
| description | Maf transcription factors form a distinct subfamily of the basic leucine zipper (bZip) transcription factors []. Maf genes have been identified in a wide range of higher eukaryotes, including both vertebrate and invertebrate species. These proteins are unique among the bZip factors in that they contain a highly conserved extended homology region (EHR), or ancillary DNA binding region, in addition to a typical basic region, and both regions are involved in target DNA sequence recognition. Maf transcription factors regulate tissue-specific gene expression and cell-differentiation in a wide variety of tissues and are also involved in human diseases and oncogenic transformation. Tissue-specific expression invloves Maf binding to Maf-recognition elements (MAREs) in the regulatory regions of target genes, and interacting with other transcription factors.This entry includes the Maf protein from vertebrates and V-MAF from Avian musculoaponeurotic fibrosarcoma virus AS42 []. |
