| Primary Identifier | IPR028546 | Type | Family |
| Short Name | Klotho |
| description | Klotho (named after a Greek goddess Klotho who spins the thread of life) was first identified as a gene disrupted in a mouse strain that inherited a syndrome resembling human ageing in an autosomal recessive manner []. Klotho is related to glycoside hydrolase and have two forms,membrane Klotho and secreted Klotho. Membrane Klotho forms a complex with fibroblast growth factor receptors and functions as an co-receptor for fibroblast growth factor 23, while secreted Klotho functions as a humoral factor that regulates activity of multiple glycoproteins on the cell surface []. The secreted Klotho may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signalling []. Overexpression of Klotho in mice can extend life span [].Mutations in human Klotho cause the tumoral calcinosis, hyperphosphatemic, familial (HFTC): a severe metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues []. |
