| Primary Identifier | IPR028597 | Type | Family |
| Short Name | LZTS2 |
| description | Leucine zipper putative tumor suppressor 2 (LZTS2, also known as LAPSER1) interacts with p80 katanin and regulates katanin-mediated microtubule severing []. It is localised to the centrosome and the midbody in mitotic cells. During prophase, LAPSER1/LZTS2 inhibits centrosomal gamma-tubulin accumulation, which results in retardation of mitotic entry. During interphase, LAPSER1/LZTS2 inhibits katanin, which results in prevention of cell motility []. LAPSER1/LZTS2 also modulates beta-catenin signaling and localisation []. LAPSER1/LZTS2 has been identified as a candidate tumor suppressor gene in prostate cancer []. |
