| Primary Identifier | IPR038075 | Type | Homologous_superfamily |
| Short Name | RalF_C_sf |
| description | The Legionella pneumophila protein RalF is a guanine nucleotide exchange factor (GEF) of ADP-ribosylation factors (Arfs), activating and recruiting host Arf1 to the Legionella-containing vacuole []. RalF contains an N-terminal Sec7 domain and a C-terminal domain known as Sec7-capping domain (SCD). The Sec7 domain of RalF has the same overall folded structure seen in eukaryotic Sec7 domains. The eukaryotic Sec7 domain is a catalytic domain found in guanine nucleotide exchange factors (GEFs) that is sufficient to activate Arf by stimulating GDP/GTP exchange []. Structural studies showed that the C-terminal domain of RalF associates with the Sec7 domain to block access to the Arf-binding site []. This entry represents the C-terminal domain of RalF []. |
