| Primary Identifier | IPR030757 | Type | Family |
| Short Name | MCT1 |
| description | Monocarboxylate transporter 1 (MCT1), also known as SLC16A1, belongs to the MCT family. It facilitates unidirectional proton-linked transport of L-lactate across the plasma membrane [, ]. Several natural occurring substrates for MCT1 have been found, including L-lactate, pyruvate, beta-hydroxybutyrate, and acetoacetate []. Inhibition of MCT1 during T lymphocyte activation results in selective and profound inhibition of the extremely rapid phase of T cell division essential for an effective immune response. Therefore, MCT1 has been used as a target for immunosuppressive therapy [, ].Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [, ]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7. Four mammalian isoforms, MCTs 1-4, have been identified, each with distinct substrate and inhibitor affinities []. MCT1-4 have been linked to cancer maintenance and aggressiveness []. |
