| Primary Identifier | IPR002120 | Type | Family |
| Short Name | TRH_rcpt_1 |
| description | Thyrotropin-releasing hormone, also known as thyroliberin (TRH) stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary [, ]. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin []. In the CNS, TRH stimulates a number of behavioural and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens []. TRH initiates all of these effects by interacting with receptors that belong to a class of G protein-coupled receptors, rhodopsin-type (GPCRA) [].There are two thyrotropin-releasing hormone receptors, thyrotropin-releasing hormone receptor (TRH1) which has been found in a number of species including rat, mouse and human [, , ]and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents [, ]. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain [, , ]. The receptors activate phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, probably of the Gq/G11 class [, ]. This entry represents the thyrotrophin-releasing hormone receptor. |
