| Primary Identifier | IPR033673 | Type | Family |
| Short Name | LsrF |
| description | Autoinducers are signal molecules involved in quorum sensing, the process of chemical communication that bacteria use to assess cell population density and synchronize behaviour. The molecule (S)-4,5-dihydroxy-2,3-pentanedione (DPD) is produced by many different species of bacteria and is the precursor of the signal molecule autoinducer-2 (AI-2).A variety of bacterial species have the ability to sequester and process the AI-2 present in their environment, thereby interfering with the cell-cell communication of other bacteria. This process involves the lsr operon, induced by AI-2. This operon consists of a transport system that facilitates uptake of the signal, a kinase that phosphorylates the signal to phospho-DPD (P-DPD), and enzymes that are responsible for processing the phosphorylated signal, thereby terminating induction of the lsr operon [].One of the enzymes responsible for processing the phosphorylated signal is LsrF. LsrF catalyzes the transfer of an acetyl moiety from 3-hydroxy-5-phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA []. |
