| Primary Identifier | IPR038168 | Type | Homologous_superfamily |
| Short Name | TF_DP_C_sf |
| description | The transcription factor DP (dimerization partner) forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer []and negatively regulates the G1-S transition. Though originally the role of DP in transcriptional activation was thought to be facilitating the binding of E2F to target DNA, it was latter shown that the C-terminal acidic region of DP1 binds strongly to the PH domain of p62 of TFIIH and acts as a transactivation domain []. |
