| Primary Identifier | IPR014183 | Type | Family |
| Short Name | ADH_3 |
| description | Class III alcohol dehydrogenases (ADH3) () tend to show poor activity for ethanol among their various substrate alcohols. They catalyze the oxidation and reduction of a wide variety of substrates that include S-(hydroxymethyl)glutathione (HMGSH), S-nitrosoglutathione, and long chain primary alcohols and aldehydes []. The enzyme was previously designated as glutathione-dependent formaldehyde dehydrogenase, as it acts as a HMGSH dehydrogenase (). ADH3 oxidizes HMGSH to S-formylglutathione, which is then hydrolyzed to glutathione and formate by a hydrolase [, ]. S-(hydroxymethyl)glutathione can form spontaneously from formaldehyde and glutathione, and constitutes a cellular strategy for sequestering and metabolizing highly toxic formaldehyde []. |
