| Primary Identifier | IPR028643 | Type | Family |
| Short Name | ING1 |
| description | Members of the ING (inhibitor of growth protein) family of tumour suppressors regulate cell cycle progression, apoptosis, and DNA repair as important cofactors of p53. Inhibitor of growth protein 1 (ING1) is the best characterised member of this family of five genes (ING1-5) with conserved plant homeodomains (PHDs) [].ING1 interacts with proliferating cell nuclear antigen (PCNA) and PCNA-interacting protein p15 (PAF) [, ]. p53 and ING1 have been shown to functionally cooperate in the activation of apoptosis []. ING1 could also induce apoptosis by translocation from the nucleus to the mitochondria where interaction with BAX stabilises this protein, promoting its pro-apoptotic function []. ING1 functions in DNA demethylation []and has a role in the early steps of multiple DNA repair pathways []. |
