| Primary Identifier | IPR028621 | Type | Family |
| Short Name | DEAD_helicase_SrmB |
| description | RNA helicases from the DEAD-box family are found in almost all organisms andhave important roles in RNA metabolism, such as splicing, RNA transport,ribosome biogenesis, translation and RNA decay. They are enzymes that unwinddouble-stranded RNA molecules in an energy dependent fashion through thehydrolysis of NTP. DEAD-box RNA helicases belong to superfamily 2 (SF2) ofhelicases. As other SF1 and SF2 members they contain seven conserved motifswhich are characteristic of these two superfamilies [].DEAD-box is named after the amino acids of motif II or Walker B (Mg2+-bindingaspartic acid). SrmB is a DEAD-box RNA helicase that is involved in ribosome assembly. Deletion of the srmB gene in Escherichia coli causes a slow-growth phenotype at low temperature []. |
