| Primary Identifier | IPR026026 | Type | Family |
| Short Name | HIT_Hint |
| description | HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides. On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified in the literature into three major branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, which consists of diadenosine polyphosphate hydrolases, and the GalT branch, consisting of specific nucleoside monophosphate transferases. Further sequence analysis reveals several new, closely related, yet uncharacterised subgroups. This group includes bacterial proteins which are members from the Hint branch of hydrolases. For additional information please see [, , , , , ]. |
