| Primary Identifier | IPR028675 | Type | Family |
| Short Name | LPP3 |
| description | Type 2 lipid phosphate phosphohydrolases (LPPs), formerly known as phosphatidic acid phosphatases (PAPs), are enzymes that catalyse the hydrolysis of a variety of lipid phosphate mono-esters, including lysophosphatidic acid (LPA), PA, diacylglycerolpyrophosphate, S1P and ceramide 1-phosphate (C-1-P). These are lipid mediators that exert complex effects on cell function through actions at cell surface receptors and on intracellular targets []. Type 2 LPPs are membrane bound enzymes, Mg2+-independent and N-ethylmaleimide-insensitive []. In humans, at least three genes coding for type 2 LPP enzymes have been identified (LPP1, LPP2 and LPP3).LPP3, also known as PPAP2B, is essential to the formation of the chorioallantoic placenta and extraembryonic vasculature. It also mediates gastrulation and axis formation, probably by regulating the Wnt signaling pathway []. A common PPAP2B polymorphism is associated with increased risk of coronary artery disease in humans []. |
