| Primary Identifier | IPR016698 | Type | Family |
| Short Name | Numb/numb-like |
| description | This group represents Protein numb and similar proteins from animals. This protein plays key roles in cell fate determination []. Members of this protein family contain a PID domain, a type of PTB domain []. NUMB from Drosophila is required in determination of cell fate during sensory organ formation in embryos []. It recruits alpha-Adaptin, and this physical interaction plays a role in downregulating Notch, presumably by stimulating endocytosis of Notch [, ]. Numb-related protein 1 (NUMB1) from Caenorhabditis elegans is involved in the tethering and targeting of pkc-3 to modulate the intracellular distribution of the kinase []. Mammalian Numb-like protein (NUMBL) plays a role in the process of neurogenesis and is required throughout embryonic neurogenesis to maintain neural progenitor cells []. It inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-kappaB activation []. It has a role in tumorigenesis []. |
