| Primary Identifier | IPR038051 | Type | Homologous_superfamily |
| Short Name | XRCC4-like_N_sf |
| description | XRCC4 is essential for non-homologous DNA end joining (NHDJ) in eukaryotes, which is required for double-strand break repair, and V(D)J recombination in immunoglobulin and T-cell receptor genes. XRCC4 forms a complex with DNA ligase IV, and acts as a regulatory element required for the stability and activity of the ligase. XRCC4 forms an elongated dumb-bell-like tetramer consisting of a C-terminal stalk that interacts with DNA ligase IV and an N-terminal globular head. The N-terminal head domain consists of a beta sandwich and a helix-turn-helix (HTH) motif, which may be involved in DNA binding [, ].This N-terminal domain is structurally similar in XRCC4 and non-homologous end-joining factor 1, also known as XRCC4-like (XLF), consisting of seven-stranded antiparallel β-sandwich with a helix-turn-helix motif inserted between β-strands 4 and 5 [, ]. |
