| Primary Identifier | IPR037299 | Type | Domain |
| Short Name | TRIM37_MATH |
| description | This entry represents the MATH (meprin and TRAF homology) domain found in TRIM37, which is a member of the tripartite motif (RING, B-Box, and coiled-coil domains) family and has E3 ubiquitin ligase activity toward itself and histone H2A protein []. TRIM37 localizes to peroxisomes []. Mutations in the human TRIM37 gene (also known as MUL) cause Mulibrey (muscle-liver-brain-eye) nanism, a rare growth disorder of prenatal onset characterized by dysmorphic features, pericardial constriction and hepatomegaly []. TRIM37 contains a tripartite motif and a MATH domain C-terminal to the coiled-coil domain. |
