| Primary Identifier | IPR019947 | Type | Family |
| Short Name | Photolyase_8HDF |
| description | This entry describes a narrow clade of cyanobacterial deoxyribodipyrimidine photolyase (or DNA photolyase). This group, in contrast to several closely related proteins, uses a chromophore that, in other lineages is modified further to become coenzyme F420. This chromophore is called 8-HDF in most articles on the DNA photolyase and FO in most literature on coenzyme F420. This entry includes PhrA from Synechocystis sp. strain PCC 6803. PhrA is a DNA photolyase responsible for the majority of the observed UV resistance in Synechocystis 6803 [, ]. The cryptochrome and photolyase families consist of structurally related flavin adenine dinucleotide (FAD) proteins that use the absorption of blue light to accomplish different tasks. The photolyasess use the blue light for light-driven electron transfer to repair UV-damaged DNA, while the cryptochromes are blue-light photoreceptors involved in the circadian clock for plants and animals [, ]. On the basis of the primary structure, the cryptochrome/DNA photolyase family can be grouped into two classes []. The first class contains cryptochromes and DNA photolyases from eubacteria, archaea, fungi, animals and plants. The second class contains DNA photolyases from prokaryotes, plants and animals. |
