| Primary Identifier | IPR016902 | Type | Family |
| Short Name | VPS41 |
| description | This entry represents the eukaryotic Vacuolar protein sorting-associated protein 41 (Vps41), a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex, which is essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport [, , ]. This protein interacts with Caspase-8, which plays a key role in apoptosis and development []. In humans, Vps41 variants prevent the formation of a functional HOPS complex, causing disorders such as dystonia associated with lysosomal abnormalities and neurodegenerative diseases [, , ]. |
