| Primary Identifier | IPR004923 | Type | Family |
| Short Name | FTR1/Fip1/EfeU |
| description | Fungi uptake extracellular ferrous iron (Fe2+) using a bipartite high-affinity transporter consisting of a multicopper ferroxidase associated with a membrane permease which translocates generated ferric iron (Fe3+) into the cytosol. The Saccharomyces cerevisiae (Baker's yeast) iron permease FTR1 is a plasma membrane permease for high-affinity iron uptake []. FTR1, together with multicopper oxidase FET3, mediate high-affinity iron uptake. Schizosaccharomyces pombe Fio1 (ferrous iron oxidase) and Fip1 (ferriferous permease), share significant similarity to FET3 and FTR1 from S. cerevisiae []. In Neosartorya fumigata, the high affinity iron permease is known as FtrA [].Many bacteria possess Fe2+ transporters with functional similaritiesto the FET3-FTR1 system. Escherichia coli encodes an EfeUOB transporter where EfeU is homologous to the high-affinity iron permease FTR1 of Saccharomyces cerevisiae [, ]. Bacillus subtilis encodes similar proteins, but not identical to the E. coli EfeUOB transporter components. B. subtilis EfeUOB uses a transport system that permits the high-affinity acquisition of both Fe2+ and Fe3+ [].This entry also includes the vacuolar iron transporter FTH1 []. |
