| Primary Identifier | IPR004912 | Type | Family |
| Short Name | Adeno_VII |
| description | Adenoviruses encode a highly basic protein called protein VII that resembles cellular histones. Protein VII forms complexes with nucleosomes, limiting DNA accessibility, and sequesters protein HMGB1 in the chromatin. HMGB1 is normally released in response to inflammatory stimuli and mediates activation of immune responses. This is thought to be part of a viral strategy to control extracellular immune signaling []. Protein VII also plays a role in packaging the viral DNA []. |
