| Primary Identifier | IPR041989 | Type | Domain |
| Short Name | PKc_TOPK |
| description | This entry represents the catalytic domain found in TOPK, which belongs to a superfamily that contains other protein kinases, such as RIO kinases, aminoglycoside phosphotransferase, choline kinase and phosphoinositide 3-kinase.Lymphokine-activated killer T-cell-originated protein kinase (TOPK), also called PDZ-binding kinase (PBK), is activated at the early stage of mitosis and plays a critical role in cytokinesis []. It partly functions as a mitogen-activated protein kinase (MAPK) kinase and is capable of phosphorylating p38, JNK1, and ERK2. TOPK also plays a role in DNA damage sensing and repair through its phosphorylation of histone H2AX [, ]. It contributes to cancer development and progression by downregulating the function of tumour suppressor p53 and reducing cell-cycle regulatory proteins [, ]. |
