| Primary Identifier | IPR041998 | Type | Domain |
| Short Name | 7tmA_HRH3 |
| description | This entry represents the 7TM domain found in histamine H3 receptor (HRH3 or H3R), which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation []. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis []. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils []. |
