| Primary Identifier | IPR001397 | Type | Family |
| Short Name | 5HT5A_rcpt |
| description | 5-hydroxytryptamine (5-HT) or serotonin, is a neurotransmitter that it is primarily found in the gastrointestinal (GI) tract, platelets, and in the central nervous system (CNS). It is implicated in a vast array of physiological and pathophysiological pathways. Receptors for 5-HT mediate both excitatory and inhibitory neurotransmission, and modulate the release of many neurotransmitters including glutamate, GABA, dopamine, epinephrine/norepinephrine, and acetylcholine, as well as many hormones, including oxytocin, prolactin, vasopressin and cortisol. In the CNS, 5-HT receptors can influence various neurological processes, such as aggression, anxiety and appetite and, as a, result are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics and anorectics []. The 5-HT receptors are grouped into a number of distinct subtypes, classified according to their antagonist susceptibilities and their affinities for 5-HT. With the exception of the 5-HT3 receptor, which is a ligand-gated ion channel [], all 5-HT receptors are members of the rhodopsin-like G protein-coupled receptor family [], and they activate an intracellular second messenger cascade to produce their responses. This entry represents the 5-HT5A receptor, which couples to G proteins and negatively influences cAMP []. It has also been shown to function, in part, through the regulation of intracellular Ca2+ mobilisation []. In the CNS, the 5-HT5A receptor is found in the cerebral cortex, hippocampus, habenula, olfactory bulb and granular layer of the cerebellum [, , ]. It may play a role in sleep []and serve as an presynaptic serotonin autoreceptor []. |
