| Primary Identifier | IPR028847 | Type | Family |
| Short Name | CENP-W |
| description | Centromere protein W (CENP-W) is a component of the CENPA-NAC (nucleosome-associated) complex, which plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation []. CENP-W gene is up-regulated in various types of cancers and was first identified as a putative oncogene, CUG2 []. It can be regulated by CSN5, a component of the CSN complex involved in protein degradation via the ubiquitin-proteasome pathway []. The DNA-binding regions in CENP-T or CENP-W is essential for inducing positive supercoils into DNA and for the kinetochore targeting of the CENP-T-W-S-X complex []. |
