| Primary Identifier | IPR043205 | Type | Family |
| Short Name | CYB561/CYBRD1-like |
| description | This entry represents a group of transmembrane reductases, including CYBRD1/CYB561/CYB561A3 from humans.Cytochrome b561 is a ferric-chelate reductase that reduces Fe3+ to Fe2+ before its transport from the endosome to the cytoplasm. It probably uses ascorbate as an electron donor [, ].Cytochrome b reductase 1 (CYBRD1) is an iron-regulated ferric reductase that catalyses the reduction of ferric to ferrous ion in the process of iron absorption in duodenal enterocytes [, ]. It shares protein sequence similarity with cytochrome b561, an enzyme involved in the regeneration of ascorbic acid (AA) from semi dehydroascorbic acid (DHA) or ascorbate free radical (AFR) []. CYB561A3 is a lysosomal membrane ascorbate-dependent ferrireductas. |
