| Primary Identifier | IPR041857 | Type | Domain |
| Short Name | Noc2_FYVE |
| description | Rab effector Noc2 (also known as RPH3AL) is a Rab3 effector that mediates the regulation of secretory vesicle exocytosis in neurons and certain endocrine cells []. It also functions as a Rab27 effector and is involved in isoproterenol (IPR)-stimulated amylase release from acinar cells [, ]. Noc2 contains an N-terminal Rab3A effector domain which harbors a conserved zinc finger, but lacks tandem C2 domains. The FYVE domain of Noc2 resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif []. |
