| Primary Identifier | IPR026205 | Type | Family |
| Short Name | PIBF1 |
| description | Progesterone-induced-blocking factor 1 (PIBF1) is an immunomodulatory molecule secreted by pregnancy lymphocytes []. It exerts immunosuppressive effects by inhibiting NK cell activity, polarising immune responses towards TH2 dominance and down-regulating effector cytokine response []. It is thought to play a vital role in preventing rejection of the embryo by the maternal immune response. PIBF1 may also have a role in cancer. It is produced by malignant tumours and may facilitate tumour growth by suppressing local antitumour immune responses []. |
