| Primary Identifier | IPR026241 | Type | Family |
| Short Name | GIP4 |
| description | Faithful chromosome segregation depends on the opposing activities of the budding yeast Glc7/PP1 protein phosphatase and Ipl1/Aurora protein kinase. It is believed that Glc7 ensures accurate chromosome segregation by dephosphorylating Ipl1 targets (rather than regulating the Ipl1 kinase) [].Gip3 and Gip4 have been identified amongst several genes as ipl1 dosage suppressors, and encode proteins that physically interact with Glc7 []. Over-expression of the GIP3 and GIP4 suppressors was shown to alter Glc7 localisation, indicating they are previously unidentified Glc7 regulatory subunits, and that Gip3 and Gip4 over-expression may impair Glc7's mitotic functions. It has been proposed, therefore, that over- expression of Glc7 regulatory subunits can titrate Glc7 away from relevant Ipl1 targets, thereby suppressing ipl1-321 cells by restoring the balance of phosphatase/kinase activity []. |
