| Primary Identifier | IPR030415 | Type | Family |
| Short Name | CASTOR1 |
| description | CASTOR1 can form homodimers and bind arginine. It can also form heterodimers with GATOR2. The arginine binding of CASTOR1 disrupts the CASTOR1-GATOR2 interaction, and this triggers downstream activation of mTORC1 []. Therefore, CASTOR1 functions as an intracellular arginine sensor for the mTORC1 Pathway [, ]. Interestingly, CASTOR1 shares substantial structural homology with the lysine-binding regulatory domain of prokaryotic aspartate kinases []. |
