| Primary Identifier | IPR038528 | Type | Homologous_superfamily |
| Short Name | TEL2_C_sf |
| description | This entry represents a conserved domain found in a group of proteins called telomere-length regulation TEL2, or clock abnormal protein-2, which are conserved from plants to humans. These proteins regulate telomere length and contribute to silencing of sub-telomeric regions []. In vitro the protein binds to telomeric DNA repeats. Tel2 acts at an early step of the TEL1/ATM pathway of DNA damage signaling []. The structure of Tel2 consists of HEAT-like helical repeats that assemble into two separate α-solenoids []. This entry represents the C-terminal solenoid which consists of eleven helices. |
