| Primary Identifier | IPR006059 | Type | Family |
| Short Name | SBP |
| description | Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-binding protein. In Gram-negative bacteria the solute-binding proteins are dissolved in the periplasm, while in archaea and Gram-positive bacteria, their solute-binding proteins are membrane-anchored lipoproteins [, ]. On the basis of sequence similarities, the vast majority of these solute-binding proteins can be grouped into eight family clusters [], which generally correlate with the nature of the solute bound. This entry represents the family 1. Family 1 members include:Maltose/maltodextrin-binding proteins of Enterobacteriaceae (gene malE) []and Streptococcus pneumoniae malXMultiple oligosaccharide binding protein of Streptococcus mutans (gene msmE)Escherichia coli glycerol-3-phosphate-binding proteinSerratia marcescens iron-binding protein (gene sfuA) and the homologous proteins (gene fbp) from Haemophilus influenzae and NeisseriaE. coli thiamine-binding protein (gene tbpA) Interestingly, these thiamin-binding proteins share protein structural similarity with thiaminase-I. They may be evolved from a common ancestor []. This entry also includes thiaminase-1 from Paenibacillus thiaminolyticus (Bacillus thiaminolyticus). |
