| Primary Identifier | IPR026489 | Type | Domain |
| Short Name | CXC_dom |
| description | Polycomb group (Pc-G) proteins ensure the stable inheritance of expressionpatterns through cell division and regulate the control of cell proliferation.The Enhancer of zeste (E(z))-type of Pc-G proteins includes:Drosophila melanogaster Enhancer of zeste E(z).Mammalian ENX-1 and ENX-2.Arabidopsis thaliana CURLY LEAF (CLF), a transcriptional repressor offloral homeotic gene AGAMOUS.Arabidopsis thaliana CLF-like.Arabidopsis thaliana MEDEA (MEA), a suppressor of endosperm development.Arabidopsis thaliana EZA1.These proteins contain a SET domain at the C terminus.Unique to them is the presence of a CXC domain, an ~65-residue cys-rich regionpreceding the SET domain. The spacing of 17 cyteines is conserved. The CXCdomain contains three units of C-X(6)-C-X(3)-C-X-C motif, although the most C-terminal unit is reverse-oriented. Because of its evolutionary conservation,the CXC domain is likely to be involved in an important function of E(z)-related proteins [, , ].The CXC domain shows some similarity to the CRC domain found in the tesmin/TSO1 protein family []. |
