| Primary Identifier | IPR044469 | Type | Domain |
| Short Name | TRBP2_DSRM_1 |
| description | TRBP2 was first identified as a HIV-1 TAR RNA-binding protein []. TRBP2 is a component of the RISC loading complex (RLC), which functions in RNA-mediated gene silencing (RNAi). It is a double-stranded RNA (dsRNA)-binding protein that associates with endonuclease Dicer, which cleaves precursor RNA molecules to produce microRNAs (miRNAs) and short interfering RNAs (siRNAs) in RNAi pathway []. Together with another dsRNA-binding protein, PACT, they function as key regulators of miRNA and siRNA biogenesis by Dicer in substrate recognition, binding, processing and RISC loading []. TRBP2 contains three double-stranded RNA binding motifs (DSRMs). This entry represents the first DSRM of TRBP2. |
