| Primary Identifier | IPR002789 | Type | Domain |
| Short Name | HerA_central |
| description | This entry represents the central domain of archaeal protein HerA, which is a DNA helicase able to utilise either 3' or 5' single-stranded DNA extensions for loading and subsequent DNA duplex unwinding []. It forms a complex with NurA nuclease, this complex has the 5'-3' DNA end resection activity and is essential for cell viability in the crenarchaeon Sulfolobus islandicus []. Studies in Sulfolobus tokodaii revealed that HerA was able to unwind blunt-ended double-stranded DNA with low efficiency and it was also able to unwind Holliday junction, splayed-arm DNA, as well as 5'- or 3'-overhang with high efficiency []. This domain includes the the central RecA-like catalytic core a flanking four-helix bundle []. |
