| Primary Identifier | IPR014764 | Type | Family |
| Short Name | DCN-prot |
| description | The eukaryotic defective in cullin neddylation (DCN) protein family, contributes to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. These multi-protein complexes are required for polyubiquitination and subsequent degradation of target proteins by the 26S proteasome[, , ]. Proteins in the DCN family include:Yeast DCN1.Vertebrate DCN1-like protein 1-5.Plant Defective in cullin neddylation protein AAR3 [].DCN family proteins all contain a Potentiating neddylation (PONY) domain (), contains a cullin-binding surface within its C-terminal region and is sufficient to promote neddylation [, ]. The N-terminal region of the protein often contains a UBA-like domain. |
