| Primary Identifier | IPR024135 | Type | Family |
| Short Name | LAMTOR5 |
| description | Hepatitis B X-interacting protein (HBXIP, also known as LAMTOR5) was originally recognised for its association with the X protein of hepatitis B virus (HBV) and ability to down-regulate HBV replication []. When complexed to the anti-apoptotic protein survivin, HBXIP interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerised APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway []. HBXIP is one of the Ragulator components that are required for mTORC1 activation by amino acids []. It is also part of the AA (amino acid) sensing machinery in human CD4+ T cells []. |
