| Primary Identifier | IPR000186 | Type | Family |
| Short Name | IL-5 |
| description | This entry represents interleukin-5 (IL5), also known as eosinophil differentiation factor (EDF),is a lineage-specific cytokine for eosinophilpoiesis [, ]. It regulates eosinophil growth and activation [], and thus plays an important role indiseases associated with increased levels of eosinophils, including asthma[]. IL5 has a similar overall fold to other cytokines (e.g., IL2, IL4 and GCSF)[], but while these exist as monomeric structures, IL5 is a homodimer. Thefold contains an anti-parallel 4-α-helix bundle with a left handed twist,connected by a 2-stranded anti-parallel β-sheet [, ]. The monomers areheld together by 2 interchain disulphide bonds []. |
