| Primary Identifier | IPR037858 | Type | Domain |
| Short Name | RhoGAP_ARAP |
| description | This entry represenst a RhoGAP (GTPase-activator protein [GAP]for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) are dual GTPase activating proteins (GAPs) for Arf and Rho family GTPases, and contain, besides the Rho-GAP domain, an Arf-GAP, ankyrin repeat ras-associating, and PH domains. Since their Arf-GAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling [, , , ].Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude [, , ]. |
