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Protein Domain : Takeout superfamily

Primary Identifier  IPR038606 Type  Homologous_superfamily
Short Name  To_sf
description  Takeout (To) proteins are found in insects and have important roles in various aspects of their physiology and behavior. To was discovered in Drosophila melanogaster as a clock-regulated gene, acting as a molecular link between circadian rhythms and feeding behavior [, ]. In addition, To is secreted in the hemolymph of adult males and affects male courtship behavior []. To proteins have an unusual α/β-wrap fold, the so-called TULIP fold [], seen also in juvenile hormone-binding proteins (JHBPs), with which they share limited sequence similarity. This fold is thought to constitute a scaffold for the binding and/or transport of hydrophobic ligands [, ].

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