| Primary Identifier | IPR038677 | Type | Homologous_superfamily |
| Short Name | WIF_sf |
| description | Wnt morphogens control embryonic development and homeostasis in adult tissues. In vertebrates the N-terminal WIF domain (WIF-1WD) of Wnt inhibitory factor 1 (WIF-1) binds Wnt ligands.This entry represents the WIF domain, it is found in the RYK tyrosine kinase receptors and WIF the Wnt-inhibitory-factor. The domain is extracellular and contains two conserved cysteines that may form a disulphide bridge. This domain is Wnt binding in WIF, and it has been suggested that RYK may also bind to Wnt []. The WIF domain of WIF-1 was suggested to have a function in inhibiting Wnt signalling []. |
