| Primary Identifier | IPR038678 | Type | Homologous_superfamily |
| Short Name | Spondin_N_sf |
| description | Spondins are multi-domain extracellular matrix (ECM) protein as well as contact-repellent molecules that directs axon outgrowth and cell migration during development. Spondins are involved in patterning axonal growth trajectory through either inhibiting or promoting adhesion of embryonic nerve cells [].This superfamily represents a domain found in the N-terminal half of several Spondin proteins [], also called FS domain. It is found in F-spondins (spondin-1), mindins (spondin-2). Its homology to a common Ca2+- and lipid-binding C2 domain suggests that the F-spondin FS domain is responsible for part of the membrane targeting of F-spondin in its regulation of axon development []. |
