| Primary Identifier | IPR036002 | Type | Homologous_superfamily |
| Short Name | Stathmin_sf |
| description | Stathmin [](from the Greek 'stathmos' which means relay), is a ubiquitous intracellular protein, present in a variety of phosphorylated forms. It is involved in the regulation of the microtubule (MT) filament system by destabilising microtubules. It prevents assembly and promotes disassembly of microtubules []. However, when phosphorylated, its destabilisation ability is significantly reduced []. The stathmin family also includes:Stathmin 2 (Protein SCG10); a neuron-specific, membrane-associated proteinthat accumulates in the growth cones of developing neurons. It is highlysimilar in its sequence to stathmin, but differs in that it contains anadditional N-terminal hydrophobic segment of 32 residues which is probablyresponsible for its interaction with membranes.Stathmin 3 (SCG10-like protein; SCLIP) []; a protein specificallyexpressed in neurons.Stathmin 4 (Stathmin-like protein B3); which contains an additional N-terminal hydrophobic domain [].These proteins possess a stathmin-like domain (SLD) with various N-terminal extensions. SLD is a highly conserved domain of 149 amino acid residues. Structurally, it consists of an N-terminal domain of about 45 residues followed by a 78 residue α-helical domain consisting of a heptad repeat coiled coil structure and a C-terminal domain of 25 residues [, ]. The SLD binds two tubulins arranged longitudinally, head-to-tail, in protofilament-like complexes. |
