| Primary Identifier | IPR030259 | Type | Family |
| Short Name | CLIC-1 |
| description | Intracellular chloride ion channel proteins (CLICs) has been shown to exist in both soluble and integral membrane forms. Chloride intracellular channel protein 1 (CLIC1) can insert into membranes and form chloride ion channels []. Membrane insertion seems to be redox-regulated and may occur only under oxydising conditions []. Channel activity has been shown to have a strong pH dependence []. The soluble form of CLIC1 is monomeric and structurally homologous to the glutathione S-transferase superfamily, with a redox-active site resembling glutaredoxin [].CLIC-1 (also known as NCC27) is involved in regulation of the cell cycle []. |
