| Primary Identifier | IPR002924 | Type | Family |
| Short Name | Adenovir_t-Ag_E1B_19kDa |
| description | This family consists of adenovirus E1B 19kDa protein or small t-antigen. The E1B 19kDa protein inhibits E1A induced apoptosis and hence prolongs the viability of the host cell []. It can also inhibit apoptosis mediated by tumour necrosis factor alpha and Fas antigen []. E1B 19kDa blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein []. The E1B region of adenovirus encodes two proteins E1B 19kDa the small t-antigen as found in this family and E1B 55kDa thelarge t-antigen which is not found in this family; bothof these proteins inhibit E1A induced apoptosis []. |
