| Primary Identifier | IPR000335 | Type | Family |
| Short Name | Bleomycin-R |
| description | Bleomycin (Blm) is a glycopeptide antibiotic produced naturally by actinomycetes. It is a strong DNA-cutting agent and thus finds use as a potent anti-cancer drug. The DNA-cutting mechanism is complex, involving concomitant oxidation of FeII and reduction of oxygen. Inaddition to iron, Blm binds other transition metals: cobalt, nickel, copper and zinc. Actinomycetes have developed a defence mechanism against this lethal compound, producing a protein that confers resistance to Blm through drug sequestering.The crystal structure of the bleomycin resistance protein reveals 2identically-folded halves, each having an alpha/beta fold but showing nosequence similarity []. Each half comprises a 4-stranded β-sheet anda short α-helix (3 turns). The sheets within each half lie roughly atright-angles and are related by an approximate 2-fold axis. The crystalpacking shows compact dimers that have a hydrophobic interface and areinvolved in mutual chain exchange. |
