| Primary Identifier | IPR012320 | Type | Domain |
| Short Name | SHD_dom |
| description | Human stonins, like their Drosophila homologue stoned B, are supposed to beendocytotic proteins involved in clathrin-mediated endocytosis at synapses.The two human stonins, as well as their Drosophila melanogaster (Fruit fly) and Caenorhabditis elegans homologues, exhibit a modular structure consisting ofan N-terminal proline- and serine-rich domain, a central stonin homologydomain (SHD), and a C-terminal domain homologous to the signal-binding domainof the mu subunits of adaptor protein (AP) complexes (mu-homology domain). The ~140 amino-acid SHD domain has not been described in other proteins and may thus be unique to members of the stonin family. Its function is not yet known [, ]. |
